This isn't a substitution.
It's a REDUCTION.
The Big Bang Theory Season 1, Episode 7
a prison sentence REDUCTION,
that in one or two years you’ll be out.
Money Heist Season 1, Episode 11
But there's been
a significant REDUCTION
in the tumors.
Breaking Bad Season 2, Episode 10
at least a 25- to 35-percent
REDUCTION in tumor mass,
Breaking Bad Season 2, Episode 9
-to the REDUCTION of scale problem.
The Big Bang Theory Season 10, Episode 19